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Navigating myasthenia gravis (MG), a chronic autoimmune disorder, can be complex.1-5 This Learning Zone will provide clinician-led, interactive content, including:

  • An overview of MG symptomatology, pathophysiology, diagnosis, and assessment
  • Current treatment strategies and guidelines
  • Persistent challenges and unmet needs

 


“Myasthenia gravis is an autoimmune disease that affects the neuromuscular junction such that the transmission of acetylcholine across the neuromuscular junction from nerve to muscle is impacted.” MG expert Amanda Hernandez (University of Connecticut School of Medicine, Farmington, USA) explains what MG is and how the disease affects patients.

Meet the expert

Professional headshot of Amanda Hernandez, MD, PhD.pngAmanda Hernandez, MD, PhD

Amanda Hernandez is Assistant Professor and Chief of Neuromuscular Medicine at the University of Connecticut School of Medicine, Farmington, USA.

Before joining the faculty, she was at Yale University (New Haven, Connecticut, USA) where she completed her MD and PhD in neuroimmunology, residency in neurology, and fellowship in neuromuscular medicine. Her research has been highly regarded, and she graduated with distinction.

Outside of her clinical practice, she is actively involved in leading innovative clinical trials, educating medical students and residents, building a curriculum focused on health systems, and facilitating translational research, with a focus on neuroinflammatory conditions including MG.

Disclosures: Consulting and advising roles for EMD Serono,* Genentech, UCB, Alexion, argenx, Johnson & Johnson, and Amgen.

*EMD Serono is the healthcare business of Merck KGaA, Darmstadt, Germany, in the US and Canada.


References

  1. Gilhus and Breiner, 2025. Chapter eight – Epidemiology of myasthenia gravis. https://doi.org/10.1016/bs.irn.2025.04.028
  2. Dresser, 2021. Myasthenia gravis: Epidemiology, pathophysiology and clinical manifestations. https://doi.org/10.3390/jcm10112235
  3. Bubuioc, 2021. The epidemiology of myasthenia gravis. https://doi.org/10.25122/jml-2020-0145
  4. NIH, 2025. Myasthenia gravis. https://www.ninds.nih.gov/health-information/disorders/myasthenia-gravis
  5. Fecto, 2025. Myasthenia gravis: Mechanisms, clinical syndromes, and diagnosis. https://doi.org/10.1016/j.disamonth.2025.101969
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